Related Experiment Video
Updated: Aug 9, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Solubilization of valsartan by aqueous glycerol, polyethylene glycol and micellar solutions
1DMI Inc., 86 N. Main Street, Wharton, NJ 07885, USA.
Abstract:
To increase the solubility of valsartan in aqueous solutions was considered of interest. This study therefore investigated the solubilization of valsartan by cosolvency and micellization. Of the solubilization agents used, sodium lauryl sulfate was found to be the most effective. The increase in solubility at the maximum concentration studied was in the following order: sodium lauryl sulfate > polysorbate-80 > polyethylene glycol 400 > glycerol. The effect of propylene glycol on the solubility of valsartan in a 2% w/v polysorbate-80 solution was also investigated and was found that propylene glycol decreased the solubilizing power of polysorbate-80 at the concentrations studied.
More Related Videos
Related Concept Videos
Bioavailability Enhancement: Drug Solubility Enhancement
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...
Bioavailability Enhancement: Drug Permeability Enhancement
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Solubility
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...

