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Updated: Aug 9, 2026
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Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
100 years of 'Allergy': can von Pirquet's word be rescued?
1Leukocyte Biology Section, NHLI Division, Imperial College, South Kensington Campus, London, UK. a.b.kay@imperial.ac.uk
Abstract:
Summary It is 100 years since Clemens von Pirquet wrote his classic paper introducing the term 'allergy'. Although the word is no longer used in the way he intended, his concept of 'changed reactivity' laid the foundation for the modern science of immunology.
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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