Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bronchopulmonary dysplasia.

John P Kinsella1, Anne Greenough, Steven H Abman

  • 1Department of Paediatrics, University of Colorado School of Medicine, Denver, USA. John.kinsella@uchsc.edu

Lancet (London, England)
|May 3, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does neonatal sepsis affect the lung function of children and adults born prematurely?

Pediatric research·2026
Same author

Ventilatory efficiency during high-frequency oscillatory ventilation with volume guarantee in preterm infants.

European journal of pediatrics·2026
Same author

Feasibility of neonatal intravenous nutrition for the management of gastroschisis in sub-Saharan Africa.

World journal of pediatric surgery·2026
Same author

Perinatal determinants of the umbilical cord pH following preterm birth.

Journal of perinatal medicine·2026
Same author

Neonatal units' visiting policies and parental experience of open-access.

Journal of perinatal medicine·2026
Same author

Early post-operative hemodynamic recovery in infants with congenital diaphragmatic hernia.

European journal of pediatrics·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
Same journal

Dual mobility total hip replacement in fractures: stability promotes patient confidence.

Lancet (London, England)·2026
Same journal

Dual mobility versus standard cups in total hip replacement for displaced femoral neck fractures (Duality): an international, multicentre, randomised, controlled, superiority trial.

Lancet (London, England)·2026
See all related articles

Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants, increasing hospital readmissions and long-term respiratory issues. Research is exploring new therapies to reduce lung injury and improve lung growth in affected infants.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Chronic Lung Disease

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant cause of morbidity and mortality in premature infants.
  • Increased survival rates of extremely premature infants have led to a rise in BPD cases.
  • BPD imposes a substantial burden on healthcare resources due to frequent hospital readmissions and persistent respiratory symptoms into adolescence.

Purpose of the Study:

  • To address the evolving understanding of BPD, including the "new BPD" characterized by chronic oxygen dependency without severe acute respiratory distress.
  • To investigate the potential for impaired postnatal lung growth as a cause of "new BPD".
  • To explore the unknown factors regarding catch-up lung growth in these infants, particularly concerning postnatal corticosteroid use.

Main Methods:

Related Experiment Videos

  • Review of current literature on BPD pathogenesis and clinical outcomes.
  • Analysis of the changing definitions and clinical presentations of BPD.
  • Identification of knowledge gaps concerning lung growth and therapeutic interventions.

Main Results:

  • The definition of BPD has evolved, with "new BPD" emerging in infants without severe acute respiratory distress, potentially linked to impaired lung growth.
  • Infants with BPD experience significant long-term respiratory issues and require frequent healthcare utilization.
  • The efficacy of postnatal corticosteroids on catch-up lung growth in BPD is currently unknown.

Conclusions:

  • Bronchopulmonary dysplasia presents an ongoing challenge in neonatal care, with increasing prevalence.
  • Further research is needed to understand the mechanisms of impaired lung growth in "new BPD".
  • Development of safe and effective preventive therapies and treatments to improve lung growth is a critical area for future study.