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Updated: Aug 9, 2026

Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate
Published on: September 18, 2013
Facile synthesis and application of uniformly 13C, 15N-labeled phosphotyrosine for ligand binding studies
Adriaan W Tuin1, Gregg Siegal, Gijsbert A van der Marel
1Leiden Institute of Chemistry, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands.
Abstract:
The first synthesis of [U-13C, 15N] labeled phosphotyrosine is described. Preliminary studies toward the binding of phosphotyrosine to an SH2 domain have been performed by means of heteronuclear NMR.
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