Related Experiment Video

Updated: Jan 8, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.2K

Economic analysis of prevaccination serotesting compared with presumptive immunization for polio, diphtheria, and

Adam L Cohen1, David Veenstra

  • 1Child Health Institute, Department of Pediatrics, University of Washington, Seattle, Washington, USA. alcohen@u.washington.edu

Pediatrics
|May 3, 2006
PubMed

Insights

For internationally adopted infants, presumptive polio immunization is more cost-effective and protective than serotesting. DTaP immunization is preferred if vaccine compliance is low or antibody prevalence is below 51%.

Area of Science:

  • Pediatric Infectious Diseases
  • Public Health Policy
  • Vaccine Economics

Background:

  • Lack of consensus on serotesting vs. presumptive vaccination for inactivated polio (IPV) and diphtheria-tetanus-acellular pertussis (DTaP) in internationally adopted/immigrant infants.
  • Need for evaluating clinical and economic outcomes of different vaccination strategies.

Purpose of the Study:

  • To compare the clinical and economic outcomes of prevaccination serotesting versus presumptive vaccination for IPV and DTaP in 12-month-old internationally adopted or immigrant infants from a societal perspective.

Main Methods:

  • Decision analysis models were developed for IPV and DTaP vaccination strategies.
  • Compared presumptive vaccination against serotesting for poliovirus antibodies (types 1, 2, 3) and diphtheria/tetanus toxoid antibodies.
  • Primary outcome measures included cost per patient protected.

Main Results:

  • Prevaccination serotesting for polio increased costs ($57 to $62) and decreased protection (95.3% to 94.0%) compared to presumptive immunization.
  • Serotesting for diphtheria and tetanus increased costs ($62 to $119) and offered marginal protection increase (91.5% to 92.3%).
  • Presumptive DTaP immunization was more cost-effective and clinically superior if >80% had poor vaccine compliance or <51% had existing antibodies.

Conclusions:

  • Presumptive polio immunization offers improved outcomes and cost savings for internationally adopted and immigrant infants compared to serotesting.
  • DTaP immunization is the preferred strategy, especially in populations with low vaccine compliance or low antibody seroprevalence.
  • The study supports presumptive immunization as the optimal approach for these infant populations.
Abstract

More Related Videos

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens09:08

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Published on: September 12, 2016

9.1K
Development of an IFN-&#947; ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.2K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
51.1K
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
1.2K
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
771
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
380
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.5K