Related Experiment Video
Updated: Aug 9, 2026
14:39
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Two isocoumarins from Pleurospermum angelicoides
Makio Shibano1, Hideyuki Naito, Masahiko Taniguchi
1Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Chemical & Pharmaceutical Bulletin
|May 3, 2006
Summary
Two novel isocoumarins, angelicoins A and B, were identified from Pleurospermum angelicoides roots. Their chemical structures were elucidated using comprehensive spectral analysis.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Pleurospermum angelicoides is a plant species with potential for novel compound discovery.
- Isocoumarins are a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new chemical constituents from Pleurospermum angelicoides roots.
- To determine the structures of newly identified isocoumarins.
Main Methods:
- Extraction of compounds from Pleurospermum angelicoides roots.
- Purification of isolated compounds using chromatographic techniques.
- Structure elucidation employing spectroscopic methods (e.g., NMR, MS).
Main Results:
- Two new isocoumarins, designated angelicoins A and B, were successfully isolated.
- The chemical structures of angelicoins A and B were definitively established through detailed spectral data interpretation.
Conclusions:
- The study expands the known chemical diversity of isocoumarins.
- Angelicoins A and B represent novel natural products from the Pleurospermum genus.