Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microglia in the aging brain.

Jessica R Conde1, Wolfgang J Streit

  • 1Department of Neuroscience, University of Florida College of Medicine, Gainesville, 32610, USA.

Journal of Neuropathology and Experimental Neurology
|May 3, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of iron accumulation and its chelation on oxidative stress in intracortical implants.

Acta biomaterialia·2025
Same author

Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease.

Pharmacological reviews·2025
Same author

Detection of molecular markers of ferroptosis in human Alzheimer's disease brains.

Journal of Alzheimer's disease : JAD·2024
Same author

Ferroptosis and pathogenesis of neuritic plaques in Alzheimer's Disease.

Pharmacological reviews·2024
Same author

Differential Glial Chitotriosidase 1 and Chitinase 3-like Protein 1 Expression in the Human Primary Visual Cortex and Cerebellum after Global Hypoxia-Ischemia.

Neuroscience·2022
Same author

Microglia states and nomenclature: A field at its crossroads.

Neuron·2022
Same journal

An unusual extra-axial supratentorial presentation of atypical teratoid/rhabdoid tumor in a child.

Journal of neuropathology and experimental neurology·2026
Same journal

Primary intracranial sarcoma, DICER1-mutant: 5 cases highlighting variable clinical and molecular features.

Journal of neuropathology and experimental neurology·2026
Same journal

Novel YWHAE-NTRK3 fusion in a pediatric glioma.

Journal of neuropathology and experimental neurology·2026
Same journal

Comprehensive clinicomolecular characterization of a methylation-defined supratentorial high-grade astrocytoma with piloid features in a young adult with confirmed germline NF1 mutation.

Journal of neuropathology and experimental neurology·2026
Same journal

Spatial mapping, isolation, and culture of primary human microglia and astrocytes: A systematic review and framework for glial cell-based models.

Journal of neuropathology and experimental neurology·2026
Same journal

Multiparameter flow cytometry of CSF identifies elevated CD8+ effector memory and TEMRA T-cells in immune-mediated neurologic disorders.

Journal of neuropathology and experimental neurology·2026
See all related articles

The aging brain shows changes in glial cells, particularly microglia. These cells may undergo senescence, leading to impaired function and potentially contributing to neurodegeneration.

Area of Science:

  • Neuroscience
  • Aging Research
  • Cellular Biology

Background:

  • The aging brain experiences decreased weight and volume, attributed to neuronal and axonal loss.
  • Glial cells, including astrocytes and microglia, increase in number and show altered reactivity in aging brains.

Purpose of the Study:

  • To review the morphologic and phenotypic changes in microglial cells during normal brain aging.
  • To explore the concept of microglial senescence as a potential driver of age-related neurodegeneration.

Main Methods:

  • Review of existing literature on microglial changes in aging.
  • Analysis of morphological and phenotypic alterations in microglia.
  • Examination of microglial activation markers and their correlation with neurodegeneration.

Related Experiment Videos

Main Results:

  • Aging is associated with increased microglial activation markers, but direct links to neurodegeneration are often unclear.
  • Microglial structural and phenotypic changes may reflect the aging process directly, rather than solely reactive gliosis.
  • Microglia may undergo cellular senescence, leading to reduced efficiency.

Conclusions:

  • Aging-related microglial changes might represent senescence rather than just inflammation.
  • Microglial senescence offers a new perspective on neurodegeneration, suggesting it can be secondary to microglial degeneration.