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Related Experiment Videos

Abnormal selective attention normalizes P3 amplitudes in PDD.

Marco R Hoeksma1, Chantal Kemner, J Leon Kenemans

  • 1Department of Psychopharmacology, Faculty of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584CA, Utrecht, The Netherlands. m.r.hoeksma@pharm.uu.nl

Journal of Autism and Developmental Disorders
|May 3, 2006
PubMed
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Children with PDD showed smaller P3 amplitudes, while adolescents exhibited abnormal selective attention. This suggests selective attention abnormalities in adolescents with PDD may normalize P3 amplitudes, acting as a compensatory mechanism.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Cognitive Science

Background:

  • Pervasive Developmental Disorders (PDD) are associated with neurodevelopmental abnormalities.
  • Previous research suggests potential alterations in event-related potentials (ERPs), including P3 amplitudes and selective attention components, in individuals with PDD.

Purpose of the Study:

  • To investigate if abnormal P3 amplitudes in PDD are linked to selective attention deficits.
  • To examine age-related differences in these neurophysiological abnormalities in children and adolescents with PDD.

Main Methods:

  • Comparison of P3 amplitudes and selective attention ERP components (auditory Processing Negativity - PN, visual N2b) between individuals with PDD and controls.
  • Analysis of age differences (children vs. adolescents) in PDD and control groups.

Related Experiment Videos

  • Utilized dipole localization to identify the neural generators of PN.

    • Main Results:

    • Children with PDD demonstrated smaller P3 amplitudes but no selective attention abnormalities compared to controls.
    • Adolescents with PDD displayed abnormal selective attention (larger PN and N2b) but normal P3 amplitudes.
    • Dipole localization indicated altered PN generator locations in individuals with PDD.

    Conclusions:

    • Selective attention abnormalities in adolescents with PDD appear to normalize P3 amplitudes, suggesting a compensatory process.
    • Age-dependent neurophysiological differences exist in PDD, impacting ERP components differently across development.