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[Alpha-tocopherol protects beta-adrenoreceptors of the rat brain from damaging effects of phospholipase A2]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|July 1, 1991
Abstract:
The effect of synaptosomal membrane phospholipid hydrolysis by phospholipase A2 and alpha-tocopherol upon the state of beta-adrenergic receptors has been studied. The damaging action of phospholipase A2 on beta-adrenergic receptors, consisting in the decrease of specific binding of 3H-dihydroalprenolol at the expense of diminishing receptor affinity and Bmax was demonstrated. It was shown, that alpha-tocopherol protects beta-adrenergic receptors from damaging effect of phospholipase A2.