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Mechanism of action of newly developed vitamin D analogue
S Okamoto1, E Ejima, T Kiriyama
1First Department of Medicine, Nagasaki University, Japan.
Contributions to Nephrology
|January 1, 1991
Abstract:
26,27-F6-1,25(OH)2D3 has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo, instead of almost equal binding to 1,25(OH)2D3 receptor and comparatively short serum half-life. To date, the mechanism of higher action is not known, but using these analogues as a mirror we might be able to elucidate the mechanism of action or the metabolism of the kidney hormone, 1,25(OH)2D3.