Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biochemical changes within a multiple sclerosis plaque in vivo.

T A Cadoux-Hudson1, A Kermode, B Rajagopalan

  • 1MRC Clinical and Biochemical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|November 1, 1991
PubMed
Summary

Magnetic resonance spectroscopy (MRS) revealed altered brain energy metabolism in multiple sclerosis (MS) lesions. Follow-up showed lesion reduction and normalized biochemistry, suggesting metabolic recovery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-HBs Immune Complex Levels: A Novel Marker of Hepatitis Flare Following Nucleos(t)ide Analog Withdrawal in HBeAg-negative Chronic Hepatitis B.

The Journal of infectious diseases·2025
Same author

Balancing Efficiency and Accuracy in Hepatitis C Rapid Antibody Testing: Insights From a Cluster Randomised Crossover Trial.

Journal of viral hepatitis·2025
Same author

An integrative re-evaluation of the <i>Fusarium sambucinum</i> species complex.

Studies in mycology·2025
Same author

Editorial: Ultralow HBsAg Levels and the Prediction of Cure in Chronic Hepatitis B.

Alimentary pharmacology & therapeutics·2025
Same author

Known from trees and the tropics: new insights into the <i>Fusarium lateritium</i> species complex.

Studies in mycology·2024
Same author

New insights into the effects of ethylene on ABA catabolism, sweetening and dormancy in stored potato tubers.

Postharvest biology and technology·2021

Area of Science:

  • Neuroimaging
  • Biochemistry
  • Neurology

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Brain energy metabolism abnormalities may occur in MS lesions.
  • Magnetic resonance spectroscopy (MRS) can assess in vivo brain biochemistry.

Purpose of the Study:

  • To investigate brain energy metabolism in a superficial multiple sclerosis (MS) lesion using MRS.
  • To monitor changes in brain biochemistry over time in relation to lesion evolution.
  • To compare phosphorus metabolism in MS lesions with that in MS patients without visible lesions.

Main Methods:

  • Magnetic resonance spectroscopy (MRS) was performed on a superficial brain lesion in a multiple sclerosis (MS) patient.
  • Phosphorus metabolite levels (e.g., phosphocreatine (PCr), adenosine triphosphate (ATP), phosphodiesters (PDE)) were quantified.

Related Experiment Videos

  • Follow-up MRS and MRI were conducted 16 months later.
  • MRS was also performed on four MS patients without visible superficial cerebral lesions.

    • Main Results:

    • Reduced phosphocreatine (PCr) relative to adenosine triphosphate (ATP) was observed in the MS lesion, indicating impaired energy metabolism.
    • An increased phosphodiester (PDE) peak was detected in the lesion.
    • Follow-up assessment showed a reduction in lesion size on MRI and normalization of intracellular biochemistry by MRS.
    • MS patients without visible superficial lesions exhibited no significant changes in phosphorus metabolism.

    Conclusions:

    • Superficial MS brain lesions exhibit abnormal energy metabolism detectable by MRS.
    • Lesion resolution is associated with the normalization of brain phosphorus metabolism.
    • MRS can serve as a valuable tool for assessing metabolic changes and recovery in MS lesions.