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Hereditary hydronephrosis in C57BL/KsJ mice.
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Laboratory Animal Science
|October 1, 1991
Summary
Hydronephrosis incidence increases with age in male C57BL/KsJ mice. Normal kidneys can develop hydronephrosis over time, suggesting a hereditary condition and a potential animal model.
Area of Science:
- Nephrology
- Animal Models
- Genetics
Background:
- Spontaneous hydronephrosis is a condition affecting the kidneys.
- Male C57BL/KsJ mice are commonly used in research.
- Understanding kidney development and disease in animal models is crucial.
Purpose of the Study:
- To investigate the age-dependent incidence of renal hydronephrosis in male C57BL/KsJ mice.
- To determine if initially normal kidneys develop hydronephrosis over time.
- To assess the potential of this strain as a model for progressive hydronephrosis.
Main Methods:
- Observational study of 234 male C57BL/KsJ mice.
- Incidence assessment based on age groups (6-8, 8-10, 11-15 weeks).
- Experimental transplantation of islet isografts under the renal capsule in mice with normal kidneys, followed by re-examination.
Main Results:
- 32% of mice exhibited spontaneous hydronephrosis.
- Hydronephrosis incidence significantly increased with age (15% to 63%, P < 0.001).
- Kidneys developing hydronephrosis post-transplantation increased with time, with 40% incidence after 4 weeks (P < 0.001).
Conclusions:
- Hydronephrosis in this mouse strain appears hereditary but not congenital.
- The condition develops rapidly and can complicate experimental outcomes.
- Male C57BL/KsJ mice may serve as a valuable model for studying progressive hydronephrosis.