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Asymmetrical weakness in polymyositis associated with neuropathic involvement
M G Cohen1, M S Schwartz, E K Li
1Department of Rheumatology, Princess Alexandra Hospital, Queensland, Australia.
Clinical Rheumatology
|December 1, 1991
Summary
Peripheral nerve involvement, rare in polymyositis and dermatomyositis, can cause asymmetrical weakness. This case highlights a novel neurological complication of polymyositis, resolving with corticosteroid treatment.
Area of Science:
- Neurology
- Rheumatology
- Clinical Neuroscience
Background:
- Polymyositis and dermatomyositis are inflammatory myopathies typically affecting proximal muscles symmetrically.
- Peripheral nerve involvement is an uncommon manifestation in these conditions.
Observation:
- A patient presented with clinically significant asymmetrical muscle weakness, mimicking an atypical form of polymyositis.
- Nerve conduction studies revealed evidence of multiple peripheral neuropathies.
Findings:
- The neurological findings suggested that peripheral neuropathy, not solely myositis, was the primary cause of the asymmetrical weakness.
- Muscle strength and neurological deficits showed significant improvement following corticosteroid therapy.
Implications:
- This case report describes a previously unrecognized neurological complication of polymyositis.
- Highlights the importance of comprehensive electrodiagnostic testing in evaluating asymmetrical weakness in inflammatory myopathies.
- Suggests that peripheral neuropathy should be considered in the differential diagnosis of polymyositis presentations.