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[Peripheral neuropathies in dysglobulinemia].

J Y Delattre1, G Saïd

  • 1Service de neurologie, La Salpêtrière, Paris.

La Revue Du Praticien
|November 15, 1991
PubMed
Summary
This summary is machine-generated.

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Peripheral neuropathies often link to dysglobulinemia, presenting varied symptoms. Early detection of dysglobulinemia is crucial for diagnosing neuropathies without clear causes.

Area of Science:

  • Neurology
  • Immunology
  • Hematology

Context:

  • Peripheral neuropathies are common neurological disorders.
  • Dysglobulinemia, including monoclonal gammopathies, Waldenström disease, multiple myeloma, and amyloidosis, can be associated with neuropathies.
  • The underlying mechanisms of neuropathy vary based on the type of dysglobulinemia.

Purpose:

  • To summarize the relationship between peripheral neuropathies and dysglobulinemia.
  • To highlight the diverse clinical and pathological features of these associated neuropathies.
  • To emphasize the importance of screening for dysglobulinemia in idiopathic neuropathies.

Summary:

  • Peripheral neuropathies frequently coexist with various forms of dysglobulinemia.
  • Neuropathies associated with "benign" monoclonal gammopathies or Waldenström disease often show autoimmune demyelination.

Related Experiment Videos

  • Neuropathies linked to multiple myeloma or amyloidosis typically result from direct tissue damage (compression, infiltration, hemorrhage).
  • Neuropathy can be the presenting or preceding symptom of an underlying dysglobulinemia, necessitating investigation.

    • Impact:

    • Increased awareness among clinicians regarding the association between neuropathy and dysglobulinemia.
    • Improved diagnostic strategies for idiopathic peripheral neuropathies.
    • Potential for earlier diagnosis and management of underlying hematological disorders.