[Peripheral neuropathies in dysglobulinemia]

Peripheral neuropathies are frequently associated with different types of dysglobulinemia. These neuropathies may have different chemical features depending on the nature of the dysglobulinemia. Most frequently it is a picture of predominantly sensory polyneuropathy. The autoimmune origin of the neuropathies with demyelination, observed in "benign" monoclonal gammopathies or some Waldenström diseases, is strongly suggested by immunohistochemical studies. Neuropathies associated with multiple myeloma or amyloidosis, are generally due to compressions, infiltrations or hemorragic destructions. The neuropathy frequently reveals and preceeds the dysglobulinemia, which should be looked for in all neuropathy without any obvious cause.