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Related Experiment Videos

Massive subchorial thrombohaematoma (Breus' mole).

D R Shanklin, J S Scott

    British Journal of Obstetrics and Gynaecology
    |June 1, 1975
    PubMed
    Summary

    Massive subchorionic thrombohaematomas, maternal blood clots separating placental layers, occur in later pregnancy. These lesions, previously thought to be early pregnancy issues linked to fetal death, are now observed in pregnancies over 25 weeks.

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    Area of Science:

    • Perinatal pathology
    • Maternal-fetal medicine
    • Obstetrics

    Background:

    • Subchorionic thrombohaematomas are maternal blood clots.
    • They separate the chorionic plate from the villous chorion.
    • This lesion is anatomically identical to Breus' mole seen in early pregnancy.

    Purpose of the Study:

    • To report on ten cases of massive subchorionic thrombohaematomas.
    • To investigate the occurrence of this lesion in later pregnancy.
    • To re-evaluate previous theories on its etiology and association with fetal death.

    Main Methods:

    • Case series analysis of ten placentae.
    • Histopathological examination of placental lesions.
    • Review of clinical data from affected pregnancies.

    Main Results:

    • Ten placentae with massive subchorionic thrombohaematomas were identified.
    • All cases were from pregnancies of at least 25 weeks' gestation.
    • Seven infants were liveborn, with three surviving the neonatal period.

    Conclusions:

    • Massive subchorionic thrombohaematomas can occur in late pregnancy.
    • Previous associations with early pregnancy and fetal death may be inaccurate.
    • The etiology of this placental lesion remains largely unknown.

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