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Translating the concept of suppressor/regulatory T cells to clinical applications

Alessandra Franco1, Salvatore Albani

  • 1Department of Medicine and Pediatrics, University of California, San Diego, La Jolla, California 92093-0731, USA.

International Reviews of Immunology
|May 4, 2006
PubMed

The in vivo expansion of suppressor/regulatory T cells (Tregs) is a desirable event in autoimmunity and transplantation. Here we summarize the general rules involved in antigen recognition by T cells and describe Tregs and their requirements, discussing different levels of immune intervention.

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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