Related Experiment Videos
Value of the cribriformity factor in grading prostatic carcinoma
C Minimo1, P H Bartels, D H Kim
1Department of Pathology, University of Chicago, Illinois 60637.
Analytical and Quantitative Cytology and Histology
|December 1, 1991
Summary
Objective grading of prostate adenocarcinoma using histometric analysis revealed gland area is useful for lower grades. Variance of cribriformity effectively grades intermediate lesions, aiding prostate cancer diagnosis.
Area of Science:
- Uropathology
- Digital Pathology
- Quantitative Histomorphometry
Background:
- Accurate grading of prostate adenocarcinoma is crucial for treatment decisions.
- The Gleason grading system relies on subjective assessment of histologic patterns.
- Objective, quantitative methods are needed to improve grading accuracy.
Purpose of the Study:
- To analyze architectural and histometric features for objective grading of prostate adenocarcinoma.
- To identify quantitative parameters correlating with Gleason grades in histologic specimens.
Main Methods:
- Analysis of prostate adenocarcinoma cases across Gleason primary grades 2 through 4B.
- Feulgen staining of tissue sections followed by microphotometry.
- Manual tracing of glandular outlines to compute gland area, lumen area, epithelium area, and cribriformity factor for 4,430 glands.
Main Results:
- Gland area and its variance showed utility in differentiating lower-grade prostate cancer.
- Variance of cribriformity emerged as a highly effective indicator for grading in the Gleason 3-4 range, particularly with cribriform glands present.
Conclusions:
- Histometric analysis of gland area and cribriformity offers objective parameters for prostate cancer grading.
- The variance of cribriformity is a promising quantitative marker for intermediate Gleason grades.