Related Experiment Video
Updated: Feb 19, 2026

Enhanced Spatial Mapping of Mouse Gastric Muscle Layers Using a Modified Swiss Roll Technique
Published on: November 25, 2025
[Experimental cytokinetic study of gastric mucosa in stress ulcer]
Abstract:
Stress ulcer was studied from the view point of cytokinetics by applying 3H-TdR double pulse labelling technique. In combination with clinical practice, the effects of three common preventive drugs Sucralfate (SCR), 25% glucose and Danshen compound were investigated. The results indicated that when stress ulcer developed, the Ts and Tc stage of gastric mucosa in the rat was much prolonged (P less than 0.01), an apparent lowering of 3H-TdR labelling index appeared (P less than 0.01), and significant impact of cytokinetic changes of mucosal cell was only seen in the region of the gastric body but not at the antral portion. SCR, 25% glucose and compound Danshen displayed a considerable protective action against ulceration and this could facilitate the recovery of Ts, Tc stage to normal range (P less than 0.01).
Related Concept Videos
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...

