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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
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Clinical implications and treatment of multiresistant Streptococcus pneumoniae pneumonia

T M File1

  • 1Summa Health System, Akron, Ohio 44304, and North-eastern Ohio Universities College of Medicine, Rootstown, Ohio, USA. filet@summa-health.org

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|May 4, 2006
PubMed

Insights

Drug-resistant Streptococcus pneumoniae (DRSP) infections are increasing due to antimicrobial use. While some drugs remain effective, continued surveillance, responsible antimicrobial use, and vaccination are crucial for managing DRSP.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Streptococcus pneumoniae is a primary cause of community-acquired respiratory infections.
  • Historically susceptible to penicillin, increased antimicrobial use since the 1990s has led to significant drug-resistant Streptococcus pneumoniae (DRSP).

Purpose of the Study:

  • To review the emergence and management of drug-resistant Streptococcus pneumoniae (DRSP).
  • To highlight effective antimicrobial agents and strategies for controlling DRSP.
  • To emphasize the need for ongoing surveillance and appropriate antimicrobial stewardship.

Main Methods:

  • Literature review of antimicrobial resistance trends in Streptococcus pneumoniae.
  • Analysis of clinical significance and effective treatment options for DRSP.
  • Evaluation of public health strategies for DRSP management.

Main Results:

  • Increased prevalence of DRSP linked to antimicrobial usage.
  • Clinical significance of resistance varies with specific antimicrobial-minimum inhibitory concentrations (MICs).
  • Agents like amoxicillin, cefotaxime, ceftriaxone, respiratory fluoroquinolones, and telithromycin show continued efficacy against DRSP.

Conclusions:

  • Effective management of DRSP requires a multi-faceted approach.
  • Continued surveillance, antimicrobial stewardship, risk stratification, and vaccination are essential.
  • Limiting the spread of DRSP necessitates coordinated public health interventions.

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