Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes observed in keratolimbal allograft.

Fumiko Maruyama-Hosoi1, Jun Shimazaki, Shigeto Shimmura

  • 1Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.

Cornea
|May 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical course and efficacy of treatment with limbal-rigid contact lens wear for ocular sequelae in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Japanese journal of ophthalmology·2025
Same author

Correlation Between Preoperative Aqueous Cytokine Levels and Mid-term Reduction of Corneal Endothelial Cells After Descemet Stripping Automated Endothelial Keratoplasty.

Cornea·2025
Same author

Impact of Intraoperative Descemet Membrane Perforation on Survival in Deep Anterior Lamellar Keratoplasty for Keratoconus.

Cornea·2025
Same author

Iridoschisis in patients with atopic dermatitis leads to intractable bullous keratopathy.

BMC ophthalmology·2025
Same author

Corneal Higher-Order Aberrations and Visual Acuity After Anterior Lamellar Keratoplasty in Treating Limbal Dermoid.

Eye & contact lens·2025
Same author

Ineffectiveness of KeraVio Treatment with Violet Light-Emitting Glasses Without Riboflavin Drops for Progressive Keratoconus.

Journal of clinical medicine·2025

Presumed immune reactions, or rejection, occurred in 13.1% of patients after keratolimbal allograft (KLAL) procedures. Managing immune suppression is crucial for successful outcomes in KLAL surgery.

Area of Science:

  • Ophthalmology
  • Immunology
  • Regenerative Medicine

Background:

  • Limbal stem cell deficiency (LSCD) causes severe visual impairment.
  • Keratolimbal allograft (KLAL) is a surgical option for LSCD.
  • Immunologic reactions can compromise KLAL graft survival.

Purpose of the Study:

  • To determine the incidence of presumed immunologic reactions after KLAL.
  • To characterize the clinical features of these reactions.
  • To assess the impact on graft outcomes.

Main Methods:

  • Retrospective analysis of 121 KLALs in 78 patients with LSCD.
  • Mean follow-up of 46.6 months.
  • Identified graft changes (epithelial defects, edema, vascular engorgement) as indicators of rejection.

Related Experiment Videos

Main Results:

  • 13.1% of KLALs (16/121) showed signs of presumed immune reaction.
  • Reactions typically occurred within 3 months post-surgery, despite immunosuppression.
  • Eyes with graft changes had significantly poorer corneal epithelialization (P < 0.0001).
  • Histology revealed lymphocyte infiltration in rejected grafts.

Conclusions:

  • Presumed limbal graft rejection affects approximately 13% of KLAL cases.
  • Effective immune suppression is vital for successful KLAL outcomes.
  • Further research into optimizing immunosuppression protocols is warranted.