[Hormonal contraception and focal nodular hyperplasia]

Hormonal contraceptives of the first generation don't have any causal influence on preexistent focal nodular liver hyperplasias, but stimulate their growth. Precondition for tumourus progression of these benign liver neoplasias is a long time pill intake. The pathogenetic mechanism for the growth of liver liver all adenomas is sure if there was a longer application of contraceptive pills containing mestranol. Characteristics of these rare tumours (incidence 3 to 4 per 100,000) are a high female prevalence of 90 to 100 per cent and a regression of little neoplasias after stopping the contraceptives. This a history of 14 years on the pill and a focal nodular hyperplasia of 8 x 6 x 4 cms.