Related Experiment Videos
Cervical spinal stenosis in metatropic dysplasia
Arabella I Leet1, Jayanth S Sampath, Charles I Scott
1Department of Orthopedic Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
Journal of Pediatric Orthopedics
|May 4, 2006
Summary
Metatropic dysplasia can cause cervical spinal stenosis, a previously undescribed condition. Prompt surgical intervention is crucial for managing spinal deformities and preventing neurological damage in affected children.
Area of Science:
- Orthopedics
- Genetics
- Neurology
Background:
- Metatropic dysplasia is a rare skeletal disorder.
- It causes thoracolumbar spine collapse and kyphoscoliosis.
- Associated anomalies include odontoid hypoplasia and atlantoaxial instability.
Purpose of the Study:
- To describe the association between cervical spinal stenosis and metatropic dysplasia.
- To highlight the implications for surgical management.
Main Methods:
- Retrospective review of 13 cases of metatropic dysplasia.
- Evaluation of spinal deformity and cervical stenosis.
- Magnetic resonance imaging (MRI) to assess cord compression.
Main Results:
- Children with metatropic dysplasia showed cervical stenosis, with or without cord compression.
- This association has not been previously reported.
- Cervical stenosis has significant treatment implications.
Conclusions:
- Cervical spinal stenosis is a newly identified feature of metatropic dysplasia.
- Surgical decompression should be considered alongside spinal fusion for odontoid hypoplasia/atlantoaxial instability.
- Prompt surgical intervention is necessary to halt or reverse neurological dysfunction and improve deformity.
Related Concept Videos
01:22Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
01:30Neurulation
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...