Related Experiment Video
Updated: Aug 6, 2026

08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
[Diseases that affect both skin and oral mucosa]
Dag Sollesnes Holsen1, Anne Christine Johannessen
1Hudavdelingen, Haukeland Universitetssjukehus, 5021 Bergen.
Summary
This review covers hereditary, autoimmune, and inflammatory diseases affecting both skin and oral mucosa. Familiarity with these conditions is crucial for medical and dental professionals.
Area of Science:
- Dermatology
- Oral Medicine
- Immunology
Context:
- Diseases affecting both skin and oral mucosa are diverse.
- Includes hereditary, autoimmune, and inflammatory conditions.
- Literature review and expert experience form the basis of this article.
Purpose:
- To present and categorize diseases affecting both skin and oral mucosa.
- To highlight the clinical presentations and diagnostic procedures.
- To emphasize the importance of interdisciplinary knowledge for healthcare professionals.
Summary:
- Common conditions like lichen planus, erythema multiforme, and lupus erythematosus generally have a good prognosis.
- Less common but severe bullous diseases (pemphigoid, pemphigus) often necessitate immunosuppressive therapy.
- Potentially life-threatening conditions include Stevens-Johnson syndrome, toxic epidermal necrolysis, and severe epidermolysis bullosa.
Impact:
- Enhances understanding of mucocutaneous diseases.
- Informs diagnostic and treatment strategies for clinicians.
- Underscores the need for medical and dental professionals to be knowledgeable about these overlapping conditions.
Related Concept Videos
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Oral Cavity
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Assessment of the Mouth
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

