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Published on: December 5, 2025
[Noninvasive ventilation for obstructive sleep apnea hypopnea syndrome in children]
Jing Zhao1, Ya-mei Zhang, Kun-ling Shen
1Department of Otorhinolaryngology, Affiliated Beijing Children's Hospital of Capital University of Medical Sciences, China. zhaojing307@sohu.com
Insights
Noninvasive ventilation (NV) effectively treats obstructive sleep apnea hypopnea syndrome (OSAHS) in children. This safe treatment, using nasal continuous positive airway pressure (nCPAP), improves key respiratory and oxygen saturation metrics.
Area of Science:
- Pediatric Sleep Medicine
- Respiratory Medicine
- Critical Care
Background:
- Obstructive sleep apnea hypopnea syndrome (OSAHS) is a significant condition in children.
- Noninvasive ventilation (NV) is a potential therapeutic option for pediatric OSAHS.
Purpose of the Study:
- To evaluate the efficacy and safety of noninvasive ventilation (NV) for treating children diagnosed with obstructive sleep apnea (OSA).
Main Methods:
- Twenty-one children with confirmed OSAHS underwent polysomnography (PSG) or ambulatory screening.
- Nasal continuous positive airway pressure (nCPAP) treatment was administered, with compliance monitored.
- Paired t-tests were used to compare pre- and on-nCPAP parameters.
Main Results:
- nCPAP treatment significantly reduced the apnea-hypopnea index (AHI) from 80.8/h to 6.7/h (P <0.01).
- Lowest oxygen saturation (SpO2) improved from 0.557 to 0.862 (P <0.01).
- Time with SpO2 <0.90 decreased from 42.9% to 1.1% (P <0.01).
Conclusions:
- Noninvasive ventilation (NV), specifically nCPAP, is a safe and effective treatment for pediatric OSAHS.
- nCPAP can be utilized as both a short-term and long-term home therapy for children with OSAHS.
Objective:
To study the efficacy and safety of noninvasive ventilation (NV) for treating children with obstructive sleep apnea.
Methods:
Twenty-one children confirmed obstructive sleep apnea hypopnea syndrome (OSAHS) with full-night polysomnography (PSG) or ambulatory screening device were enrolled in the study. The NV treatment was carried out successfully for all cases. Nasal continuous positive airway pressure (nCPAP) compliance data were gathered via clinical follow-up examination, telephone interview, or mailed questionnaire. The statistical analysis was performed with SPSS 11.0 statistical software. Pre- and on-nCPAP parameters were compared with paired t-test. Twenty-one OSAHS children (17 boys, 4 girls) were enrolled into the study. The mean age of the children was 4. 5 years; ranging from 40 days to 11 years.
Results:
nCPAP pressure was increased from 4 cm H2O by (1 cm H2O = 0.098 kPa) 0.2 cm H2O each time to the treating pressure which was between 4.8 and 16 cm H2O. Before nCPAP treatment, apnea hypopnea index (AHI) was (80.8 +/- 45.1)/h, the lowest pulse oxygen saturation (SPO2) 0.557 +/- 0.135 and SPO2 <0.90 time during sleep (42.9 +/- 31.9) %, which were much worse compared to that with nCPAP treatment, the above parameters decreased to (6.7 +/- 12.4)/h, 0.862 +/- 0.082, (1.1 +/- 2.5) % respectively(P <0.01).
Conclusions:
Noninvasive ventilation is a safe and effective treatment for OSAHS children. It is possible to use nCPAP as a short-term treatment or as a long-term treatment at home.
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