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Updated: Aug 8, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
[Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation]
Lan Deng1, Heng Huang, Ming-xia Xu
1West China School of Pharmacy, Sichuan University, Chengdu 610041, China. denglan234@sina.com
Aim:
To search for compounds through structural modification of cyclovirobuxine D, using 20 or 21-aminosteroids as lead compound for the treatment of cerebrovascular diseases with better lipid peroxidation inhibitory activity.
Methods:
According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.
Results:
Four new compounds were obtained and confirmed by spectra.
Conclusion:
Lipid peroxidation inhibitory effects of cyclovirobuxine D analogues were tested by using TBA method. Some compounds showed better activity than that of cyclovirobuxine D.
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