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Updated: Aug 4, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
Published on: June 18, 2012
Activity of nitric oxide synthase and concentration of nitric oxide end metabolites in the gingiva under experimental
V L Popkov1, I A Fil'chukova, N V Lapina
1Krasnodar Branch, Southern Bureau, Russian Academy of Medical Sciences, Moscow.
Abstract:
Parameters of NO metabolism in the gingiva were studied during experimental periodontitis accompanied by alloxan diabetes and exogenous hypercholesterolemia. We measured activities of inducible and constitutive NO synthase and concentrations of stable NO end metabolites in rat gingival tissue (total contents of nitrite and nitrate). Under pathological conditions NO-metabolism significantly differed from the control. Treatment with mexidol for 14 days significantly decreased activity of inducible NO synthase in the gingiva of experimental animals.

