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Updated: Aug 8, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Unusual temperature dependence of enantioselectivity in asymmetric reductions by chiral NADH models
Ryota Saito1, Shoichiro Naruse, Koji Takano
1Department of Materials and Life Science, Seikei University, Musashino, Japan. rsaito@st.seikei.ac.jp
Abstract:
[reaction: see text] Unusual stereoselectivity changes, i.e., enhancement and inversion of enantioselectivity with increasing temperature, were observed in the asymmetric reduction of methyl benzoylformate with chiral 1,4-dihydropyridines possessing amino acid residues as ligating chiral auxiliaries. The differential activation parameters, DeltaDeltaH(S-R) and DeltaDeltaS(S-R), obtained from the Eyring plots demonstrate that the entropy term controls the enantiodifferentiating step, accounting for the observed unique temperature dependencies.
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