Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Shape-selective fluorescent sensing ensemble using a tweezer-type metalloreceptor.

Jeffrey P Plante1, Timothy E Glass

  • 1Department of Chemistry, University of Missouri-Columbia, 65211, USA.

Organic Letters
|May 5, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluorescent Sensor for the Visualization of Amino Acid Neurotransmitters in Neurons Based on an S<sub>N</sub>Ar Reaction.

ACS chemical neuroscience·2025
Same author

Imaging Neurotransmitters with Small-Molecule Fluorescent Probes.

Angewandte Chemie (International ed. in English)·2024
Same author

Synthesis of a Near-Infrared Fluorescent Probe for Imaging Catecholamines via a Tandem Nucleophilic Aromatic Substitution.

Organic letters·2023
Same author

A Turn-On Fluorescent Amino Acid Sensor Reveals Chloroquine's Effect on Cellular Amino Acids via Inhibiting Cathepsin L.

ACS central science·2023
Same author

A novel method for the synthesis of 1,2-benzisoxazoline-3-one and its application to hypochlorite recognition.

Journal of materials chemistry. B·2020
Same author

A novel water-soluble fluorescence probe based on ICT lighten for detecting hydrogen sulfide and its application in bioimaging.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2019
Same journal

Ir-Catalyzed Formal 1,2-Fluorine Migration in Fluorocarbenes.

Organic letters·2026
Same journal

Leveraging Bayesian Optimization for Accelerated Ligand Selection in Atroposelective Negishi Coupling.

Organic letters·2026
Same journal

Synthesis of Azido Energetic Compounds Based on 2-(Pyrazol-4-yl)pyrazolo[4,3-<i>e</i>][1,2,4]triazolo[1,5-<i>c</i>][1,2,3]triazine via an Atom-Economical Intramolecular Dutt-Wormall-Type Process.

Organic letters·2026
Same journal

Modular Synthesis of Dinitramino-Functionalized Pyrazole-Tetrazole and Its Derivatives: Achieving Superior Detonation Performance.

Organic letters·2026
Same journal

Light-Driven Iron-Catalyzed Decarboxylative Fluorosulfonylation of Aliphatic Carboxylic Acids.

Organic letters·2026
Same journal

Chiral Phosphoric Acid-Catalyzed Enantioselective Dearomative Spirocyclization of Phenol-Ynamides by Kinetic Resolution.

Organic letters·2026
See all related articles

A novel fluorescent sensor detects pyridine-based compounds. This sensor uses a copper-coordinated bisimidazole pyridine receptor and a quenched dye, releasing the dye to signal the presence of guests like adenine with increased fluorescence.

Area of Science:

  • Supramolecular Chemistry
  • Analytical Chemistry
  • Chemical Sensing

Background:

  • Development of selective sensors for heteroaromatic compounds is crucial.
  • Existing methods may lack sensitivity or specificity for pyridine derivatives.
  • Fluorescent sensing offers high sensitivity and real-time detection capabilities.

Purpose of the Study:

  • To design and synthesize a novel fluorescent sensing ensemble.
  • To detect pyridine-derived compounds using a supramolecular approach.
  • To achieve sensitive and selective guest recognition via fluorescence modulation.

Main Methods:

  • Preparation of a bisimidazole pyridine receptor.
  • Coordination of copper ions to form a defined binding cavity.

Related Experiment Videos

  • Incorporation of a fluorescent dye quenched by copper.
  • Monitoring fluorescence changes upon guest binding.

    • Main Results:

    • The bisimidazole pyridine receptor successfully coordinated copper ions.
    • A well-defined cavity was formed, capable of binding small heteroaromatic guests like adenine.
    • Guest binding induced the release of the quenched fluorescent dye.
    • Fluorescence intensity increased up to 25-fold upon guest complexation.

    Conclusions:

    • A functional fluorescent sensing ensemble for pyridine-derived compounds was successfully developed.
    • The ensemble demonstrates strong binding affinity for specific heteroaromatic guests.
    • The developed sensor shows significant potential for sensitive detection applications.