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Updated: Aug 8, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Magnitude and time course of arterial vascular adaptations to inactivity in humans
Patricia C E de Groot1, Michiel W P Bleeker, Maria T E Hopman
1Department of Physiology, Radboud University Nijmegen Medical Center, The Netherlands.
Abstract:
We demonstrate that extensive arterial vascular adaptations occur within 3-8 wk of inactivity in humans. We put forth the hypothesis that the diameter decrease represents an adaptation to a lack of variation in peak shear stress. Furthermore, an enhanced flow-mediated dilation in deconditioned arteries implies that functional vascular adaptations to inactivity are not simply the inverse of adaptations to exercise.
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