Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genotype related differences in beta2 adrenergic receptor density and cardiac function.

Eric M Snyder1, Minelle L Hulsebus, Stephen T Turner

  • 1Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA. snyder.eric@mayo.edu

Medicine and Science in Sports and Exercise
|May 5, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of psychological and physiological responses to auditory and visual stimuli during recovery from acute stress induction.

Physiology international·2026
Same author

Influence of brief carbon dioxide inhalation on acute exercise performance and recovery: A pilot study.

Physiological reports·2026
Same author

Quantitative assessment of inspiratory loading on postprandial glycemia and metabolic response in healthy adults.

Scientific reports·2026
Same author

Evaluating the semi-chronic effects of household air pollution exposure on cardiopulmonary health under two different ventilation conditions.

Scientific reports·2026
Same author

Interrogating pulmonary diffusing capacity in long COVID: insights from DLCO and DLNO testing.

Frontiers in physiology·2025
Same author

Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude.

Physiological reports·2025

The Arg16Gly polymorphism of the beta2 adrenergic receptor (ADRB2) affects receptor density, influencing resting cardiac output and stroke volume in healthy individuals. This genetic variation impacts baseline cardiovascular function.

Area of Science:

  • Cardiovascular Physiology
  • Pharmacogenetics
  • Molecular Biology

Background:

  • Common polymorphisms in the beta2 adrenergic receptor (ADRB2) gene exist, including a Glycine (Gly) for Arginine (Arg) substitution at amino acid 16.
  • Previous studies suggest Arg16Gly polymorphism influences agonist-mediated desensitization, but baseline differences in receptor function or density were also proposed.
  • This study investigated if ADRB2 genetic variation impacts ADRB2 density and resting cardiovascular function.

Purpose of the Study:

  • To determine if the Arg16Gly polymorphism of the ADRB2 gene influences ADRB2 density.
  • To assess the consequent impact on resting cardiovascular function, including cardiac output, heart rate, and stroke volume.

Main Methods:

  • Measured ADRB2 density on isolated lymphocytes in 30 healthy subjects (15 Arg16 homozygous, 15 Gly16 homozygous).

Related Experiment Videos

  • Subjects were matched for age, BMI, fitness, and gender.
  • Measured resting cardiac output (Q), heart rate (HR), and stroke volume (SV) after 5 minutes of rest.

    • Main Results:

    • Arg16 subjects exhibited significantly lower ADRB2 density compared to Gly16 subjects.
    • Arg16 subjects had lower resting cardiac output and stroke volume, with a higher heart rate than Gly16 subjects.
    • ADRB2 density was positively correlated with cardiac output and stroke volume across all subjects.

    Conclusions:

    • The Arg16Gly polymorphism of the ADRB2 receptor influences receptor density.
    • This variation in receptor density contributes to observed differences in resting cardiac output and stroke volume.
    • Genetic variation in ADRB2 impacts baseline cardiovascular parameters.