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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
Combined oral and topical mesalazine treatment for extensive ulcerative colitis
Alan C Moss1, Adam S Cheifetz, Mark A Peppercorn
1Center for Inflammatory Bowel Disease, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. amoss@bidmc.harvard.edu
Background:
A 32-year-old white Jewish woman was referred to our clinic in October 2002 for a second opinion on the management of her active extensive ulcerative colitis that did not respond to oral mesalazine (mesalamine) 3.6 g/day. The severity of symptoms had affected her plans to have children.
Investigations:
Laboratory investigations, including perinuclear antineutrophil cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae, stool cultures, and sigmoidoscopy to 40 cm from the rectum, with biopsies.
Diagnosis:
Moderate-to-severe active extensive ulcerative colitis, unresponsive to mesalazine at 3.6 g/day.
Management:
Oral mesalazine 4.8 g/day and 4 g mesalazine enemas nightly.
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