Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macroporous elastomeric scaffolds with extensive micropores for soft tissue engineering.

Jin Gao1, Peter M Crapo, Yadong Wang

  • 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, 30332-0535, USA.

Tissue Engineering
|May 6, 2006
PubMed
Summary

Researchers created macroporous scaffolds using poly(glycerol sebacate) (PGS), a biocompatible elastomer ideal for soft tissue engineering. The novel fabrication method yields scaffolds with controlled porosity and interconnected pores, supporting cell growth.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The protective effect of S-adenosylmethionine on chronic adolescent stress-induced depression-like behaviors by regulating gut microbiota.

European journal of pharmacology·2024
Same author

Selective Hydrogenolysis Conversion of Polyethylene into Alkyl Oil Over Iridium-based Catalyst.

ChemSusChem·2024
Same author

Functional Characterization of Six Eukaryotic Translation Initiation Factors of <i>Toxoplasma gondii</i> Using the CRISPR-Cas9 System.

International journal of molecular sciences·2024
Same author

Research on ride comfort optimization of the vehicle considering the subframe.

Science progress·2024
Same author

First report of PST-producing Microseira wollei from China reveals its novel toxin profile.

Harmful algae·2024
Same author

Amino-Acid-Encoded Supramolecular Nanostructures for Persistent Bioluminescence Imaging of Tumor.

Advanced healthcare materials·2024

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Macroporous scaffolds are crucial for tissue engineering applications.
  • Poly(glycerol sebacate) (PGS) is a promising biocompatible and biodegradable elastomer.
  • Existing fabrication methods may lack control over scaffold architecture.

Purpose of the Study:

  • To develop a novel method for fabricating macroporous scaffolds from poly(glycerol sebacate) (PGS).
  • To characterize the structural properties of the fabricated PGS scaffolds.
  • To evaluate the suitability of PGS scaffolds for soft tissue engineering.

Main Methods:

  • Fabrication of macroporous PGS scaffolds using sodium chloride (salt) crystals as porogens.
  • Fusion of salt crystals in a mold, followed by PGS curing.

Related Experiment Videos

  • Dissolution of salt template and lyophilization to yield porous elastomer sponges.

    • Main Results:

    • Achieved approximately 90% porosity with interconnected macropores (75-150 µm) and extensive micropores (5-20 µm).
    • Demonstrated good control over pore size, porosity, and interconnectivity.
    • Fibroblasts adhered well and proliferated within the PGS scaffolds, forming 3D constructs in 8 days.

    Conclusions:

    • The developed method effectively produces macroporous PGS scaffolds with desirable structural features for tissue engineering.
    • The unique microporous structure may enhance cell-cell interactions and mass transport.
    • PGS scaffolds show significant potential for soft tissue engineering applications.