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No association between chronic musculoskeletal complaints and Val158Met polymorphism in the
Knut Hagen1, Elin Pettersen, Lars Jacob Stovner
1Department of Clinical Neuroscience; Norwegian University of Science and Technology, Trondheim, Norway. knut.hagen@ntnu.no
Background:
The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype.
Methods:
In the 1995-97 Nord-Trøndelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals.
Results:
The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups.
Conclusion:
In this population-based study, no significant association was found between Val/Met polymorphism at the COMT gene and chronic MSCs.
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