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Dose effects in gene environment interaction: an enzyme kinetics based approach.

Seymour Garte1

  • 1Molecular Carcinogenesis Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5150 Center Av Suite 1A, Pittsburgh, PA 15232, USA. gartesj@upmc.edu

Medical Hypotheses
|May 6, 2006
PubMed
Summary

Genetic variations influence drug and toxin responses differently at various doses. A new hypothesis suggests gain-of-function polymorphisms cause low dose effects, while loss-of-function polymorphisms cause high dose effects, impacting risk analysis.

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