Related Experiment Video
Updated: Aug 8, 2026
08:08
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
Hemiarch replacement during pregnancy (19 weeks) utilizing normothermic selective cerebral perfusion
Hitoshi Matsuda1, Hitoshi Ogino, Reiko Neki
1Department of Cardio-Vascular Surgery, National CardioVascular Center, Suita, Osaka, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan. hitmat@hsp.ncvc.go.jp
Summary
This case study details a successful surgical repair of an ascending aortic aneurysm in a pregnant patient with Marfan syndrome. The procedure allowed the continuation of pregnancy and resulted in a healthy delivery.
Area of Science:
- Cardiovascular Surgery
- Maternal-Fetal Medicine
- Cardiology
Background:
- Marfan syndrome presents significant risks during pregnancy, particularly aortic dissection.
- Aortic dissection in pregnant patients requires urgent and complex management.
- This case highlights the challenges of managing aortic emergencies in pregnancy.
Observation:
- A 20-year-old pregnant woman (19 weeks) with Marfan syndrome presented with ascending aortic dissection.
- The patient desired to continue her pregnancy.
- Cardiotocography and trans-esophageal echocardiography monitored fetal well-being.
Findings:
- A successful hemi-arch replacement using a Dacron graft was performed under cardiopulmonary bypass.
- Selective cerebral perfusion was employed to protect the brain during aortic repair.
- The patient maintained peripheral pressure above 80 mmHg.
- Body temperature was passively reduced to 35°C.
Implications:
- This surgical approach demonstrates the feasibility of managing complex aortic pathologies in pregnant patients.
- Successful outcomes are possible with meticulous surgical planning and execution.
- This case contributes to the understanding of managing Marfan syndrome during pregnancy, prioritizing both maternal and fetal health.
