Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Keeping time without a clock.

Ben Collins1, Justin Blau

  • 1Biology Department, New York University, 100 Washington Square East, New York, New York 10003, USA.

Neuron
|May 6, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Social information processing in autism: The role of cognitive empathy in moral responding.

Journal of neuropsychology·2026
Same author

Global leadership for existential challenges: findings from the third meeting of the Commonwealth Leadership Institute.

BMJ leader·2026
Same author

Best practices for the collection and analysis of patient experience data from social media for patient-focused drug development.

Frontiers in medicine·2026
Same author

A dimensional analysis of autism: The role of basic socio-cognitive skills for social competence in children.

Journal of neuropsychology·2026
Same author

Outcomes and Workflow in a Titanium Powder Bed Fusion Cranial Reparation Surgery Service.

3D printing and additive manufacturing·2025
Same author

A rapid and dynamic role for FMRP in the plasticity of adult neurons.

Nature communications·2025
Same journal

Dynamic coordination and segregation mechanisms in higher cortex for parallel task processing.

Neuron·2026
Same journal

Higher-order thalamic bursts are drivers of attention control.

Neuron·2026
Same journal

Composing trajectories for rapid inference of navigational goals.

Neuron·2026
Same journal

Peri-head distance coding in the mouse brainstem.

Neuron·2026
Same journal

A two-timepoint framework for sensitive and specific single-cell activity screening.

Neuron·2026
Same journal

From first impressions to bonds: The neural dynamics of social relationships.

Neuron·2026
See all related articles

The transcription factor CLOCK is thought to be central to the mammalian molecular clock. New research shows CLOCK-deficient mice have only minor clock defects, challenging this long-held view in circadian biology.

Area of Science:

  • Circadian Biology
  • Molecular Biology
  • Genetics

Background:

  • The transcription factor CLOCK is widely accepted as the core component of the mammalian molecular clock.
  • This molecular clock regulates various behavioral and physiological rhythms.

Discussion:

  • DeBruyne et al. generated CLOCK-deficient mice to investigate its role.
  • These mice exhibited only subtle defects in their circadian clock functions.
  • This finding challenges the established dogma regarding CLOCK's central role.

Key Insights:

  • CLOCK may not be as indispensable for the mammalian circadian clock as previously believed.
  • The study provides new evidence for alternative or redundant mechanisms in circadian rhythm regulation.
  • Subtle clock defects in CLOCK-deficient mice suggest a more nuanced understanding of the molecular clockwork.

Related Experiment Videos

Outlook:

  • Further research is needed to elucidate the precise mechanisms underlying circadian rhythms in the absence of a fully functional CLOCK.
  • Investigating compensatory pathways will be crucial for a comprehensive understanding of the mammalian clock.
  • This work opens new avenues for exploring circadian clock disorders and potential therapeutic targets.