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Updated: Aug 8, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
A qualitative study of amlodipine and its related compounds by electrospray ionization tandem mass spectrometry
John Gibbons1, Jonathan Pugh, Gina Dimopoulos-Italiano
1Genpharm Inc., 85 Advance Road, Etobicoke, Ontario, Canada. johng@genpharm.ca
Abstract:
A comprehensive structural analysis of amlodipine and certain related compounds was performed by electrospray ionization tandem mass spectrometry. Triple quadrupole and quadrupole time-of-flight instruments were used to provide collision-induced dissociation and accurate mass measurement for selected product and second-generation product ions. A unique ion rearrangement was observed, which was found to be characteristic of certain dihydropyridines. This study provides a fundamental understanding of the fragmentation of these compounds. The structural elucidation of an unknown impurity is presented as an example.
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