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Updated: Aug 4, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Mechanisms of enzyme catalysis from crystal structure analyses
1Institut für Organische Chemie und Biochemie der Universität, Freiburg, Germany.
Abstract:
The enzyme families to which glutathione reductase and adenylate kinase belong show appreciably different structural behaviour during catalysis. While the electron transfer in glutathione reductase requires only small movements of a couple of non-hydrogen atoms, the transfer of a phosphoryl group in the nucleotide kinases involves major rearrangements with main chain displacements of up to 32 A. In both cases, the structural changes during a catalytic cycle have been derived from a number of separate X-ray crystallographic analyses.
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