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Epidemiologic trends in infection, mortality, and transplants related to hepatitis C in Wisconsin

Mari Gasiorowicz1, Marjorie Hurie, Angela Russell

  • 1Wisconsin AIDS/HIV Program, Bureau of Communicable Diseases and Preparedness, Division of Public Health, Department of Health and Family Services, USA.

WMJ : Official Publication of the State Medical Society of Wisconsin
|May 9, 2006
PubMed

Insights

Hepatitis C virus (HCV) infection impacts many in Wisconsin, with highest rates in males, older adults, Milwaukee residents, and inmates. African Americans experience high morbidity and mortality but are underrepresented in liver transplant recipients.

Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) is a leading cause of chronic bloodborne infection in the US.
  • HCV infection affects millions nationally and tens of thousands in Wisconsin.
  • HCV contributes to significant mortality and liver transplantations annually.

Purpose of the Study:

  • To summarize epidemiologic trends of HCV infection, mortality, and liver transplants in Wisconsin.
  • To analyze surveillance data from 1997-2004 for HCV infection.
  • To examine HCV-related deaths (1995-2002) and liver transplants (1993-2004).

Main Methods:

  • Utilized surveillance data for HCV infection cases.
  • Analyzed death certificate data for HCV as a cause of death.
  • Compiled data on HCV-related liver transplantations.

Main Results:

  • 16,668 HCV cases, 1186 HCV-related deaths, and 356 HCV-related liver transplants were reported in Wisconsin.
  • Infection and adverse outcomes are highest among males, ages 35-64, Milwaukee residents, and correctional facility inmates.
  • African Americans show high morbidity and mortality but are underrepresented in transplant recipients.

Conclusions:

  • HCV disproportionately affects specific demographics within Wisconsin.
  • Targeted interventions are needed for high-risk populations.
  • Addressing disparities in liver transplantation for African Americans with HCV is crucial.

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