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Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
[A study on the influenza surveillance program in Tianjin, 2004]
Jie-xiu Wang1, Ai-lan Shan, Lu Gao
1Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
Summary
Influenza surveillance in Tianjin revealed A(H3N2) as the predominant strain. Economic analysis indicated significant potential returns from vaccination programs, especially for the 0-19 age group.
Area of Science:
- Epidemiology
- Virology
- Health Economics
Context:
- Influenza poses a significant public health challenge globally and regionally.
- Understanding epidemic trends and dominant strains is crucial for effective control strategies.
- Economic evaluation of interventions aids in resource allocation and policy-making.
Purpose:
- To investigate influenza epidemic trends and predominant strains in Tianjin.
- To analyze the economic impact of influenza vaccination for prevention and control.
- To inform public health strategies for influenza management in the region.
Summary:
- Influenza-like illness peaked between November and February, accounting for 9.39% of cases during the epidemic period.
- Type A(H3N2) was the predominant influenza strain identified (45 out of 56 isolates).
- Mathematical modeling suggested potential net returns of 24 million Yuan for the 0-19 age group with a 30% attack rate, highlighting vaccination's economic benefits.
Impact:
- Findings underscore the need for continuous, year-round influenza surveillance due to evolving strains and potential summer incidence.
- The study provides economic rationale for investing in influenza vaccination programs.
- Results can guide Tianjin's public health authorities in optimizing influenza prevention and control measures.

