[Immune response in mice induced by different doses of foot-and-mouth disease virus]

Response against foot-and-mouth disease virus 01 Campos on vaccinated female mice and suckling litter was estimated. Vaccine doses ranged between 0.05 and 30 micrograms of virus. The lower dose protected 39.5% of suckling litter whereas 100% protection was achieved using the higher doses. Serum neutralization indexes in females, at 45 days post vaccination, ranged from 3.60 to 4.86 for 0.05 microgram to 0.10 microgram and 4.86 to 5.50 for the high doses. Although the doses were excessively high (eq. 1 mu/g average live weight) and (OH)3Al was used as adjuvant, no adverse effect on the immune system was detected in any of the vaccinated animals.