Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Connexin43: emerging role in erectile function.

Georges Pointis1

  • 1INSERM U 670, Faculté de Médecine, IFR 50, 28 Avenue de Valombrose, 06107 Nice Cedex 02, France. pointis@unice.fr

The International Journal of Biochemistry & Cell Biology
|May 9, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cooperative cell-cell actin network remodeling to perform Gap junction endocytosis.

Basic and clinical andrology·2023
Same author

Effects of a mixture of low doses of atrazine and benzo[a]pyrene on the rat seminiferous epithelium either during or after the establishment of the blood-testis barrier in the rat seminiferous tubule culture model.

Toxicology in vitro : an international journal published in association with BIBRA·2019
Same author

Multiple and complex influences of connexins and pannexins on cell death.

Biochimica et biophysica acta. Biomembranes·2017
Same author

Effects of low doses of carbendazim or iprodione either separately or in mixture on the pubertal rat seminiferous epithelium: An ex vivo study.

Toxicology in vitro : an international journal published in association with BIBRA·2017
Same author

Physiological roles of connexins and pannexins in reproductive organs.

Cellular and molecular life sciences : CMLS·2015
Same author

New cellular mechanisms of gap junction degradation and recycling.

Biology of the cell·2015
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

Connexins form gap junctions crucial for tissue function. Connexin43 plays a key role in human erectile function, showing potential for medical applications in this area.

Area of Science:

  • Cellular Biology
  • Physiology
  • Medical Science

Background:

  • Connexins are proteins forming gap junction channels, vital for intercellular communication.
  • Gap junctions regulate tissue homeostasis, cell proliferation, and differentiation.
  • Connexin gene mutations are linked to various human diseases, and altered expression correlates with tumor progression.

Purpose of the Study:

  • To review the role of connexin43 in human erectile function.
  • To explore the involvement of gap junctions in smooth muscle relaxation and erectile response.
  • To discuss potential medical applications of connexin43 in erectile dysfunction.

Main Methods:

  • Literature review of studies on connexins and gap junctions.
  • Analysis of research linking connexin43 to smooth muscle function.

Related Experiment Videos

  • Examination of data on connexin expression in erectile tissues.

    • Main Results:

    • Gap junctions are critical for corporal smooth muscle relaxation and erectile response.
    • Connexin43 is highlighted as a significant protein in the physiology and pathophysiology of human erectile function.
    • Evidence suggests connexin43's involvement in maintaining normal erectile function.

    Conclusions:

    • Connexin43 has an emerging and critical role in human erectile physiology.
    • Understanding connexin43's function may lead to novel therapeutic strategies for erectile dysfunction.
    • Further research into connexin43 could unlock new medical applications for erectile health.