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Mitomycin C in the management of pediatric caustic esophageal strictures: a case report

Oluyinka O Olutoye1, Robert J Shulman, Ronald T Cotton

  • 1Pediatric Surgery Division, Michael E. DeBakey Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030-2399, USA. oolutoye@bcm.tcm.edu

Journal of Pediatric Surgery
|May 9, 2006
PubMed

Insights

Mitomycin C (MMC) shows promise in treating pediatric esophageal strictures caused by caustic ingestion. Topical MMC application improved stenosis in a child, suggesting its potential as an adjunct therapy.

Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Otolaryngology

Background:

  • Caustic esophageal strictures pose a significant management challenge, particularly in pediatric cases.
  • Mitomycin C (MMC), known to inhibit fibroblast proliferation, has demonstrated scar-reducing effects in experimental models.

Observation:

  • A pediatric case of distal esophageal stricture resulting from lye ingestion is presented.
  • Despite multiple dilatations, significant stenosis persisted at one year post-injury.

Findings:

  • Topical Mitomycin C (MMC) was applied endoscopically and repeated four months later.
  • At twenty months follow-up, the child experienced normal eating, and esophagram revealed reduced stenosis (50% of esophageal diameter).
  • No adverse complications were noted during the follow-up period.

Implications:

  • Mitomycin C (MMC) may be a valuable adjunct therapy for managing pediatric caustic esophageal strictures.
  • Further controlled clinical trials are necessary to validate the efficacy and safety of MMC in this context.

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