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Updated: Aug 8, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Metabolic alteration transients during paroxysmal activity in an epileptic patient with fixation-off sensitivity: a
Federico Giove1, Girolamo Garreffa, Stefano Peca
1Museo storico della fisica e Centro di studi e ricerche Enrico Fermi, 00184 Rome, Italy.
Abstract:
The purpose of this study was to investigate short-time metabolic variations related to continuous epileptic activity elicited by fixation-off sensitivity (FOS). Time-resolved magnetic resonance spectroscopy was performed on a patient on whom previous clinical findings clearly indicated presence of FOS. The epileptic focus was localized with a simultaneous electroencephalographic and functional magnetic resonance imaging study. The results showed a linear increase of the sum of glutamate and glutamine with time of paroxysmal activity in epileptic focus and much greater concentration of choline-containing compounds in focus than in the contralateral side.
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