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"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
Genetics of hepatobiliary diseases
Brian D Juran1, Konstantinos N Lazaridis
1Division of Gastroenterology and Hepatology, Center for Basic Research in Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Summary
Genomic discoveries offer new insights into hepatobiliary diseases, improving understanding, prevention, and treatment. Research will focus on identifying genetic variants and complex genotype/phenotype relationships for better disease pathogenesis insights.
Area of Science:
- Genomics
- Hepatology
- Medical Genetics
Background:
- The Human Haplotype Map provides a foundation for genomic discoveries impacting clinical practice.
- Hepatobiliary diseases, including common conditions like alcoholic and nonalcoholic fatty liver disease, and rarer disorders, pose significant health challenges.
- Understanding the genetic basis of these diseases is crucial for advancing patient care.
Purpose of the Study:
- To explore the potential of genomic-based approaches in understanding hepatobiliary diseases.
- To identify genetic susceptibility variants contributing to liver and gallbladder diseases.
- To elucidate complex genotype/phenotype relationships in liver diseases.
Main Methods:
- Leveraging genomic data and variation maps.
- Applying genomic-based approaches in translational studies.
- Analyzing large, well-organized patient cohorts.
Main Results:
- Genomic advancements are poised to enhance understanding of liver disease genetics.
- Opportunities exist to dissect genetic variants influencing disease susceptibility.
- Elucidating genotype/phenotype correlations will improve disease pathogenesis knowledge.
Conclusions:
- Genomic era research offers a paradigm shift in studying hepatobiliary diseases.
- Translational genomic studies are essential for dissecting disease mechanisms.
- These advancements promise improved diagnostics, prevention, and therapies for liver diseases.
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