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Related Experiment Video

Updated: Jul 23, 2026

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
15:23

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Published on: May 13, 2010

[Aptamers: selection and scope of applications].

F Chauveau1, C Pestourie, B Tavitian

  • 1CEA, département de recherche médicale, service hospitalier Frédéric-Joliot, Inserm U803, Orsay, France.

Pathologie-Biologie
|May 9, 2006
PubMed
Summary

Aptamers are short DNA or RNA molecules that bind targets like proteins with high specificity. Aptamer technology, including SELEX, enables diverse applications in therapy and diagnostics.

Area of Science:

  • Molecular Biology
  • Biochemistry

Context:

  • Aptamers are short nucleic acid sequences selected for target binding.
  • They offer high specificity and affinity comparable to antibodies.
  • Aptamers can also inhibit target molecule function.

Purpose:

  • To discuss aptamer selection principles (SELEX technology).
  • To explore the structural basis of aptamer-ligand interactions.
  • To review diverse aptamer applications.

Summary:

  • Aptamers bind targets with antibody-like specificity and affinity.
  • SELEX technology is used for aptamer selection.
  • Applications span diagnostics, therapeutics, and research tools.

Impact:

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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

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Last Updated: Jul 23, 2026

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
15:23

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Published on: May 13, 2010

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

  • Aptamers are valuable tools for biological research.
  • Approved aptamer therapies exist for diseases like macular degeneration.
  • Ongoing development for novel therapeutic and diagnostic uses.