How we interact with objects: learning from brain lesions
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Updated: Sep 26, 2026

Behavioral Assessment of Manual Dexterity in Non-Human Primates
Published on: November 10, 2011
1Department of Neuromotor Physiology, IRCCS Santa Lucia Foundation, via Ardeatina 306, 00179 Roma, Italy. e.daprati@hsantalucia.it
Abstract:
Motor deficits are the most common outcome of brain damage. Although a large part of such disturbances arises from loss of elementary sensorimotor functions, several syndromes cannot be explained purely on these bases. In this article, we briefly describe higher-order motor impairments, with specific attention to the characteristic ability of the human hand to interact with objects and tools. Disruption of this motor skill at several independent levels is used to outline a comprehensive model, in which various current proposals for a modular organization of hand-object interactions can be integrated. In this model, cortical mechanisms related to object interaction are independent from representations of the semantic features of objects.
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