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Updated: Jul 17, 2026
Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
Published on: June 6, 2016
Multiple micromanipulations for preimplantation genetic diagnosis do not affect embryo development to the blastocyst
Jeanine Cieslak-Janzen1, Ilan Tur-Kaspa, Yuri Ilkevitch
1IVF and Preimplantation Genetics Diagnosis Program, Reproductive Genetics Institute, Chicago, Illinois, USA. rgi@flash.net
Abstract:
To determine the impact of multiple micromanipulation procedures for preimplantation genetic diagnosis (PGD) on embryo development, a retrospective analysis was performed of 9,925 embryos (862 PGD cycles), which were compared with 28,126 nonbiopsied embryos (2,751 consecutive intracytoplasmic sperm injection [ICSI] cycles) from the same time period. Because fertilization rates, the proportion of embryos with > or = 6 cells on day 3, and blastocyst rates were similar in the PGD and control groups, we conclude that multiple micromanipulations on oocytes and embryos can be performed safely for PGD.
