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Related Experiment Videos

Endogenous plastic composite material in the Alzheimer's brain.

N W Seidler1, H D Craig, T J Squire

  • 1Kansas City University of Medicine and Biosciences, Department of Biochemistry, 1750 Independence Avenue, Kansas City, MO 64106, USA. nseidler@kcumb.edu

Medical Hypotheses
|May 9, 2006
PubMed
Summary

Alzheimer's disease plaques may contain plastic composites formed by acrolein polymerization, catalyzed by amyloid beta. This endogenous material could significantly contribute to Alzheimer's pathogenesis.

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Area of Science:

  • Neuroscience
  • Materials Science
  • Biochemistry

Background:

  • Alzheimer's disease (AD) is characterized by amyloid beta (Abeta) plaque accumulation in the brain.
  • These plaques may contain poorly defined structures beyond fibrous amyloid beta.

Purpose of the Study:

  • To investigate the hypothesis that plastic composite material contributes to Alzheimer's plaque formation.
  • To elucidate the role of acrolein polymerization in the pathogenesis of AD.

Main Methods:

  • Examining the chemical properties of acrolein, including its carbonyl and vinyl groups.
  • Investigating the catalytic role of Abeta in acrolein polymerization using latex chemistry principles.
  • Analyzing previously observed Abeta-polyacrolein plastic fragments.

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Main Results:

  • Acrolein, an oxidized lipid fragment, can polymerize via its functional groups.
  • Abeta's redox and surfactant properties catalyze acrolein polymerization.
  • Thin plastic fragments composed of Abeta-polyacrolein have been observed.

Conclusions:

  • The formation of Abeta-polyacrolein plastic fragments is a proposed pathway in Alzheimer's pathogenesis.
  • Endogenous plastic composite material may play a significant role in the development of Alzheimer's disease.