Related Experiment Video
Updated: Aug 3, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
L-Argininamidium bis(hydrogensquarate)
Tsonko Kolev1, Michael Spiteller, William S Sheldrick
1Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Build. 9, 1113 Sofia, Bulgaria.
This study reveals the crystal structure of 1-[4-(aminocarbonyl)butyl]guanidinium bis(hydrogensquarate). The compound forms a 3D network via hydrogen bonds between guanidinium cations and hydrogensquarate anions.
Area of Science:
- Crystal chemistry
- Supramolecular chemistry
- Organic chemistry
Background:
- Guanidinium compounds exhibit diverse hydrogen bonding capabilities.
- Hydrogensquarate anions are versatile hydrogen bond acceptors.
- Understanding crystal packing is crucial for materials science.
Purpose of the Study:
- To determine the crystal structure of 1-[4-(aminocarbonyl)butyl]guanidinium bis(hydrogensquarate).
- To investigate the intermolecular interactions governing the crystal packing.
Main Methods:
- Single-crystal X-ray diffraction analysis.
- Hydrogen bond network analysis.
Main Results:
- The crystal structure features 1-[4-(aminocarbonyl)butyl]guanidinium cations and hydrogensquarate anions.
- A three-dimensional network is formed by N-H...O hydrogen bonds between guanidinium and hydrogensquarate moieties.
- Hydrogensquarate anions form hydrogen-bonded dimers via O-H...O' interactions.
Conclusions:
- The compound self-assembles into an intricate 3D supramolecular architecture.
- Hydrogen bonding plays a critical role in stabilizing the crystal structure.
- This structural insight contributes to the understanding of organic salt crystal engineering.
More Related Videos
12:02An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
08:55Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
Published on: June 25, 2018
Related Concept Videos
Amino acids
Acid Halides to Amides: Aminolysis
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
Structure of Amines
Preparation of Amines: Alkylation of Ammonia and Amines
Each alkylation step makes the nitrogen center more nucleophilic, which triggers successive alkylations until a quaternary ammonium salt is formed. Considering...
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Diazonium Group Substitution: –OH and –H